Baclofen Forum vs Alkoholismus

The Royal College of Psychiatrists 2018

Baclofen in the treatment of alcohol dependence with or without liver disease: multisite, randomised,
double-blind, placebo-controlled trial

Kirsten C. Morley, Andrew Baillie, Isabel Fraser, Ainsley Furneaux-Bate, Glenys Dore,
Michael Roberts, Ahmed Abdalla, Nghi Phung and Paul S. Haber

Results
There was a significant effect of baclofen (composite groups) on time to lapse (χ2 = 6.44, P<0.05,
Cohen's d = 0.56) and relapse (χ2 = 4.62, P<0.05, d = 0.52). A significant treatment effect of baclofen
was observed for percentage days abstinent (placebo 43%, baclofen 30 mg 69%, baclofen 75 mg 65%; P<0.05).
There was one serious adverse event (overdose) directly related to medication (75 mg).

Merci Federico. Bemerkenswert: niedriger dosiertes Baclofen erzielt (leicht) bessere Abstinenzwerte als höher dosiert.

LG

Patrick