Hier findet Baclofen eine Erwähnung :
Can Maintenance Medications Be Used In Abstinence Based Programs?"One such medication is Baclofen. Available since the mid-1950s, Baclofen is a derivative of gamma-amino-butyric acid (GABA). Historically used to treat spasticity, Baclofen is in the early stages of research for use in the treatment of alcoholism. A notable Italian study by Addolorato G., Leggio L., Ferrulli A., Cardone S., Vonghia L., Mirijello A., Abenavoli L. and D’Angelo C. et al. (Dec 2007) found Baclofen both reduces craving and alcohol withdrawal. The most well-known publication on Baclofen has been the writings of Dr. Oliver Amesien, a French Cardiologist who has battled with alcoholism for many years. In his memoir, “The End of My Addiction” (Farrar, Straus and Giroux, 2009), Dr. Amesien had sought help from various rehabilitation centers at least eight times and attended nearly 5,000 Alcoholics Anonymous (AA) meetings without being able to maintain sobriety. Dr. Amesien then began experimenting with Baclofen, and noticed that as he increased his daily dose his cravings were greatly reduced. Most interestingly, Dr. Amesien claims he has consistently been able to abstain from drinking altogether or drink moderately in social situations without having cravings or other addiction-related problems.
Despite this well-documented memoir, Baclofen as a frontline treatment is still in its infancy. A further study conducted in conjunction with the University of Glasgow found that, “Tailored Baclofen treatment in alcohol dependent patients with medical disease reduces self-reported alcohol consumption and results in significant improvement in craving and negative consequences of drinking. There may also be improvements in depression and anxiety, but quality of life appears unaffected. The overall satisfaction with tailored Baclofen treatment is high. Baclofen is a promising treatment option for alcohol dependency, which needs further study.” (Masson et al, 2011). Despite these promising findings, all studies to date have been relatively small in scale. To counter these concerns, a further study at the University of Amsterdam was commenced in 2011."
Über die Amsterdam-Studie habe ich bisher nichts gefunden. Ich bleibe aber am Ball.
LG, Werner
