Muss nicht, kann aber gelesen werden...
(Vielleicht muss ich das künftig gar nicht mehr erwähnen).
Anmerkung Federico: accepted for publication in a peer reviewed journal
(zur Veröffentlichung angenommen in einer Peer-Review-Zeitschrift)
MEDICATION TREATMENT OF DIFFERENT TYPES OF ALCOHOLISMAm J Psychiatry. Author manuscript; available in PMC 2010 September 15.
Published in final edited form as:
Am J Psychiatry. 2010 June; 167(6): 630–639.
doi: 10.1176/appi.ajp.2010.08101500
PMCID: PMC2939449
NIHMSID: NIHMS233056
MEDICATION TREATMENT OF DIFFERENT TYPES OF ALCOHOLISM
Bankole A. Johnson, D.Sc., M.D., Alumni Professor and Chairman, Professor of Neuroscience, Professor of Medicine
Auszug:
An alternative treatment medication for this patient would be baclofen—an agonist at pre-synaptic GABA-B (bicuculline-insensitive) receptors that appears to act by modulation of G-protein-gated inwardly rectifying potassium channels (GIRK, Kir3) to suppress cortico-mesolimbic dopamine system neurons (58). Related to this patient, baclofen might be useful as it has shown promise to treat alcohol dependence, particularly among those with liver impairment (59). Baclofen is excreted primarily through the kidneys. Like topiramate, it is recommended to titrate baclofen, from a starting dose of 5 mg three times daily in the first 3 days, and then to the ceiling dose of 10 mg three times daily. Unlike topiramate, baclofen is administered to patients who have already become abstinent, possibly by the use of a reducing dose of the benzodiazepine chlordiazepoxide on an outpatient basis. While baclofen might itself aid in reducing alcohol withdrawal symptoms (60), its cessation should be gradual to avoid the emergence of withdrawal symptoms of its own such as confusion, hallucinations, anxiety, perceptual disturbance, and extreme muscle rigidity with or without spasticity. Common adverse events associated with baclofen administration include headaches, insomnia, nausea, hypotension, urinary frequency, and, rarely, excitement and visual abnormalities (61).
