Don't worry 'B' happy!: a role for GABA(B) receptors in anxiety and depression.Cryan JF, Kaupmann K.
Abstract
GABA, the main inhibitory neurotransmitter in the brain, regulates many physiological and
psychological processes. Thus, dysfunction of the GABA system is implicated in the
pathophysiology of several neuropsychiatric disorders, including anxiety and depression.
However, the role of GABA(B) receptors in behavioural processes related to these disorders
has not been resolved. GABA(B) receptors are G-protein-coupled receptors that function as
heterodimers of GABA(B(1)) and GABA(B(2)) subunits. In addition to highly selective agonists
and antagonists, novel GABA(B) receptor tools have been developed recently to further assist
elucidation of the role of GABA(B) receptors in CNS function. These include mice that lack
functional GABA(B) receptors, and novel positive modulators of the GABA(B) receptor. In this
review, we discuss evidence that points to a role of GABA(B) receptors in anxiety and depress
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