@all,
ist zwar schon 2 Jahre alt, aber sehr "inhaltsreich" :
Addiction Medicine:
Closing the Gap between Science and Practice Juni 2012
The National Center on Addiction and
Substance Abuse at Columbia University
Auch Baclofen wird erwähnt :
"Baclofen (brand names Kemstro, Lioresal and
Gablofen), a medication normally used to treat
spasticity, has been found to reduce cravings and
withdrawal symptoms in patients with addiction
involving alcohol, helping them to reduce their
drinking and to achieve and maintain abstinence;
however, the existing evidence is too limited to
recommend baclofen for addiction involving
alcohol.126 A double-blind placebo-controlled
study*
in humans found that more baclofen
patients than placebo patients achieved and
maintained abstinence (70.0 percent vs. 21.1
percent); baclofen patients also demonstrated a
larger reduction in average number of drinks,
alcohol craving, relapse rates and anxiety levels
relative to placebo patients in this study.127
There appears to be a dose-response relationship
for baclofen, with greater effectiveness at higher
doses.128"
LG, Werner
